I’m with Josh – use simple time-management skills like those in David Allen’s book Getting Things Done. I try to be stress-free when it comes to e-mails by responding immediately (50%), deleting (30%), or filing (20%) e-mails. I am one of the few who have an empty in-box. I also use other means of communications (IM, Phone, networks, text) to avoid overloading others’ in-boxes. Believe it or not, I have some co-workers whose in-boxes have reached the maximum capacity. In-boxes need to be cleaned and organized as much as one’s home or office.