How does mass originate?
Does nonbaryonic dark matter exist, and if so, in what form?
Why are we in a matter universe?
What is the ultimate fate of our universe?
What is the structure of quantum gravity?
Are quarks and leptons truly elementary, or composite?
Do the physical constants change with time?
What are the consequences of a nonzero neutrino mass?
How does one build a quantum computer?
And finally, is room temperature superconductivity possible?